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- W2347573485 abstract "Objective To study the influence of G6PD deficiency on MCV and MCH of the thalassemia gene carriers. Methods The enzyme assay and blood cell analysis were performed in pregnant women and their husbands who were confirmed as thalassemia gene carriers in prenatal screening in our hospital from June 2006 to December 2008. The carriers were divided into two groups; the G6PD deficiency group and normal G6PD group and then their MCV and MCH were compared. Results MCV and MCH in α-thalassemia-1 gene combined with G6PD deficiency group were obviously higher than those in α-thalassemia-1 gene combined with normal G6PD group ( P 0. 05 ). MCV in light β-thalassemia gene combined with G6PD deficiency group was obviously higher than that of light β-thalassemia gene combined with normal G6PD group (P 0. 05). MCH in fight p-thalassemia gene combined with G6PD deficiency group was higher than that of light p-thalassemia gene combined with normal G6PD group. However, the difference did not have statistias significance. Conclusion G6PD deficiency can influence the sensibility of MCV and MCH in thalassemia screening, leading to the missed diagnosis. Therefore, blood cell analysis, hemoglobin electrophoresis, red cell osmotic fragility test, and detection of G6PD activity are recommended to jointly screen thalassemia, aiming to increase detection rate of thalassemia gene carriers and reduce birth defects." @default.
- W2347573485 created "2016-06-24" @default.
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- W2347573485 date "2011-01-01" @default.
- W2347573485 modified "2023-09-22" @default.
- W2347573485 title "The influence of G6PD deficiency on thalassemia prenatal screening hematology index" @default.
- W2347573485 hasPublicationYear "2011" @default.
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