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- W2347596438 abstract "Objective To observe the effects of tamoxifen(TAM)on the internal organ of mice.Methods TAM was administrated to mice at different doses(0.02mg·kg~(-1)·d~(-1),0.2mg·kg~(-1)·d~(-1),2mg·kg~(-1)·d~(-1))by gavage once a day for successive 35 days.The mice were weighted and sacrificed on the 35th day.The hearts,livers and kidneys were enucleated and weighted.The pathomorphologic observation were made by light microscope.Results The ratio of liver /body had significant difference between 2mg·kg~(-1)·d~(-1) groups and negative control group(P0.05).The liver cells with fatty degeneration were observed in 2mg·kg~(-1)·d~(-1) and 0.2mg·kg~(-1)·d~(-1)TAM groups.The ratio of heart and kidney to body had no significant difference with those in negative control group.Conclusion Hepatic steatosis may occurred after lasting taking TAM." @default.
- W2347596438 created "2016-06-24" @default.
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- W2347596438 date "2005-01-01" @default.
- W2347596438 modified "2023-09-26" @default.
- W2347596438 title "Pathomorphologic Study of the Viscera of Mice under the Influence of Tamoxifen" @default.
- W2347596438 hasPublicationYear "2005" @default.
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