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- W2347597422 abstract "Objective:To investigate the influence of combined histone deacetylase inhibitor(HDACi) MS-275 and epirubicin induced cell cycle stasis and apoptosis in breast cancer cell line MCF-7,approach thire mechanism.Methods:MCF-7 cells used in the experiment were cultured in vitro. The effect of survival rate on epirubicin alone and associated with MS-275 was measured by MTT .Flow cytometry ( FCM) was used to examine the rate of apoptosis.The difference of P53 and P21 protein was estimated by Western blot.Results:Combining 5-FU and MS-275 not only decreased the survival rate but also increased the apoptosis rate with dose dependent on MCF-7.The levels of P21 and P53 protein were increased when epirubicin was used alone.The combination of two agents increased P21 and P53 protein levels more obviously than epirubicin alone.Conclusion:These results demonstrate that the combination of epirubicin and MS-275 can increase the cytotoxicity of MCF-7 cell line. The effect might be associated with the change of chromatinic conformation which was pretreated by MS-275 and the strengthen of P21 and P53 protein which was induced by epirubicin." @default.
- W2347597422 created "2016-06-24" @default.
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- W2347597422 date "2007-01-01" @default.
- W2347597422 modified "2023-09-25" @default.
- W2347597422 title "Effect of combined MS-275 and Epirubicin on breast cancer cell MCF-7" @default.
- W2347597422 hasPublicationYear "2007" @default.
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