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- W2347608082 abstract "Objective To observe the changes of serum type Ⅲprocollagen(PCⅢ) in early acute myocardial infarction(AMI) and reaction of antimyocardial fibrosis, to evaluate serum PCⅢin myocardial fibrosis with AMI.Methods The concentrations of serum PCⅢand angiotensinⅡ(AngⅡ) were measured by radioimmunoassay in 43 patients with AMI, the serum concentrations of creatine kinase isoenzymes MB(CK MB) also were measured by enzym immounoassay at the same time. These patients were divided randomly into two subgroups: conventional group 22 cases, benazepsil interventional group 21 cases.The latter were treated by incremental dosage of benazepril on conventional therapy. Normal healthy subjects were sampled and tested at the same batch. Blood was sampled in all these patients on before, 1 d, 3 d, 7 d, 14 d of therapy.Results The concentrations of serum PCⅢ,AngⅡ,CK MB in AMI were significantly higher than normal control(P 0.01 ).The concentrations of serum PCⅢ and AngⅡin conventional group reached the highest at 7 d and were significantly higher than before and 14 d of therapy(P 0.05 ).The levels of serum PCⅢ in benazepril interventional group before therapy were lower significantly than 7 d,14 d after therapy, but concentrations of AngⅡat 3 d,7 d and 14 d after therapy were lower significantly than before therapy. The concentrations of CK MB at 1d were significantly higher than any other time stages (P 0.05 ) and decreased normal at 3 d,7 d,14 d. The levels of serum PCⅢwere not related to CK MB(r= 0.2014 ,P 0.05 ),however they were positively related to AngⅡ(r= 0.5034 ,P 0.01 ).Conclusions Serum concentrations of PCⅢ is a useful marker of reflecting the degree of tissue synthesis of collagen with AMI and can be used to evaluate effect of antifibrosis therapy." @default.
- W2347608082 created "2016-06-24" @default.
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- W2347608082 date "2003-01-01" @default.
- W2347608082 modified "2023-09-24" @default.
- W2347608082 title "Serum type III procollagen in early acute myocardial infarction and its clinical significance" @default.
- W2347608082 hasPublicationYear "2003" @default.
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