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- W2347608103 abstract "To investigate the function of secondary neurons in the olfactory bulb(OB) of young adult and old cats,we applied Nissl staining to display secondary olfactory neurons,and immunostaining of glial fibrillary acid protein(GFAP) and S100 protein to show astrocytes and glial cells respectively in the external plexiform layer(EPL) of OB.Under the microscope,secondary olfactory neurons,GFAP-immunoreactive(GFAP-IR) cells and S100-immunoreactive(S100-IR) cells were observed and quantified.Furthermore,the diameter of secondary olfactory neurons and the thickness of EPL were measured.Compared to the young cats,the number of secondary olfactory neurons in old cats declined significantly(P0.05);the thickness of EPL had no evident difference(P0.05);and the density of S100-IR cells especially GFAP-IR cells in the EPL of old cats was obviously higher(P0.05).Neuron loss was accompanied with glial hyperplasia during senescence.In addition,the diameter of secondary olfactory neurons in old cats decreased significantly(P0.05),revealing functional degeneration of aged neurons in the OB.Loss of secondary olfactory neurons may be an important reason for aged olfactory degeneration,and glial enhancement in old individuals may offer nutrition to surviving neurons to postphone their further aging." @default.
- W2347608103 created "2016-06-24" @default.
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- W2347608103 date "2006-01-01" @default.
- W2347608103 modified "2023-09-25" @default.
- W2347608103 title "Age-related Morphological Changes of External Plexiform and Mitral Cell Layer in the Olfactory Bulb of Cats" @default.
- W2347608103 hasPublicationYear "2006" @default.
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