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- W2347619532 abstract "Aim:To observe the effect of hyperbaric oxygen(HBO) on the pharmacokinetics of theophylline,Methods:Six healthy volunteers were given a single dose of 300 mg aminophylline orally under normal condition and 10d later under 1h 0.25MPa(2.5ATA)NBO(with 2 HBO/d ahead )re-spectively.Venous blood specimens were drawn right before and at 0.5,1,1.5,2,3,4,6 and 8 h af- ter the oral drug administration,and UV spectrophotography was used to determine the serum concen-trations of theophylline. Results:The serum concentrations of theolihylline under 0.25 MPa HBO con-dition were lower than that of normal and the elimination half life and clearance ratio of them showed significant difference(P0.05)by the paired t-test.There were no significant changes of other phar-macokinetic parameters(P0.05).Conclusion:Higher concentration of oxygen in human body under 0.25MPA HBO my cause the cytochrome P-450 system to metabolite and eliminate theophylline more rapidly. When patients receive repeated HBO treatments with aminophylline,it is appropriate to moni- tor the blood level so as to adjust its dosage individually in order to avoid untoward results." @default.
- W2347619532 created "2016-06-24" @default.
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- W2347619532 date "1996-01-01" @default.
- W2347619532 modified "2023-09-26" @default.
- W2347619532 title "Pharmacokinetic study of theophylline under hyperbaric oxygenation" @default.
- W2347619532 hasPublicationYear "1996" @default.
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