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- W2347635591 abstract "Objective To observe the effect of valsartan/hydrochlorothiazide(HCTZ) on left ventricular hypertrophy and diastolic function in patients with mild or moderate essential hypertension(EH).Methods One hundred two patients with mild or moderate EH and left ventricular hypertrophy were divided,after elution,into groups observation(n=62,receiving valsartan 80 mg+HCTZ 12.5 mg,30 weeks) and control(n=40,receiving valsartan 80 mg,30 weeks).Blood pressure(BP),heart rate(HR),left ventricular mass index(LVMI),left ventricular isovolumic relaxation time(IVRT),early diastolic peak velocity(E)/late diastolic peak velocity(A) ratio,E peak deceleration(DT) were determined.Results BP,LVMI,IVRT,DT and E/A ratio were significantly improved 30 weeks after treatement as compared with those before treatment(P0.05).The reduction ranges of systolic and diastolic BP were significantly larger in observation group(37±10 mm Hg,22±6 mm Hg,respectively) than in control(26±10 mm Hg,11±5 mm Hg,respectively)(P0.05);the reduction ranges of LVMI,IVRT,DT(18±7 g/m2,22±9 ms,90±18 ms,respectively) were larger than in control(14±6 g/m2,18±7 ms,81±20 ms,respectively);the extent of increase was larger in observation group(0.68±0.3) than in control(0.48±0.2)(P0.05).Conclusion Both compound valsartan and valsartan treatments can reduce the BP levels of mild or moderate hypertensive patients and improve obviously left ventricular hypertrophy and diastolic function,but the former effects more remarkably." @default.
- W2347635591 created "2016-06-24" @default.
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- W2347635591 date "2010-01-01" @default.
- W2347635591 modified "2023-09-24" @default.
- W2347635591 title "Effect of Valsartan/HCTZ on Left Ventricular Hypertrophy and Diastolic Function in Patients with Primary Hypertension" @default.
- W2347635591 hasPublicationYear "2010" @default.
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