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- W2347694237 abstract "OBJECTIVE To study the physical and chemical properties of indomethacin(IMC)solid dispersion and improve the dissolution rate of the drug in simulated gastric fluid.METHODS The solid dispersion was prepared from the solution after solvent evaperation,in which IMC and carrier were dissolved.The physical characteristics of the solid dispersion were examined with powder X-ray diffraction.Dissolution behavior of IMC was studied simultaneously.RESULTS The dissolution rate of IMC was significantly improved when it was dispersed in solid dispersion.Almost one hundred percent of the drug released from the dispersion in five minutes.CONCLUSION Solid dispersion containing IMC could be prepared successfully with solvent evaperation method.IMC is able to release rapidly from the solid dispersion in which the drug exists as an amorphous state." @default.
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- W2347694237 date "2007-01-01" @default.
- W2347694237 modified "2023-09-22" @default.
- W2347694237 title "Study on preparation and physical-chemical characteristics of indomethacin solid dispersion" @default.
- W2347694237 hasPublicationYear "2007" @default.
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