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- W2347697923 abstract "Objective To investigate the effects of reformed human tumor necrosis factor|α(rhTNF|α) and bcl|2 antisense sephosphorthioate oligodeoxynucleotides(ASPO) on acute myeloid leukemic cell line HL|60, to learn more about the relationship between TNF|α and bcl|2 on apoptosis of the hematological malignancies. Methods The effects of rhTNF|α and bcl|2 ASPO on the proliferation and apoptosis of leukemic cell line HL|60 were studied by using MTT assays, flow cytometer(FCM) technique and in situ cell apoptosis detection. To detect the variation of bcl|2 oncogene expression through RT|PCR and immunohistochemical staining. Results Both rhTNF|α and bcl|2 ASPO inhibit the proliferation and induce the apoptosis of HL|60, the combinative therapy enhance the effects signigicantly. The sharply down|regulation of bcl|2 oncogene expression can also be observed. Conclusion Cytokine TNF|α in combination with bcl|2 ASPO probably have synergistic effects on apoptosis of hematological malignancies, so the regimens including cytokine and antisense oligodeoxynucleotides may provide a new way for treatment of hematological malignancies.;" @default.
- W2347697923 created "2016-06-24" @default.
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- W2347697923 date "2003-01-01" @default.
- W2347697923 modified "2023-09-25" @default.
- W2347697923 title "Synergistic Effects of rhTNF-α and bcl-2 Antisense Oligodeoxynucleotides on Proliferation and Apoptosis of HL-60" @default.
- W2347697923 hasPublicationYear "2003" @default.
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