Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347701360> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2347701360 endingPage "7" @default.
- W2347701360 startingPage "1004" @default.
- W2347701360 abstract "To find out reliable index for evaluating the anti-hepatitis B virus (HBV) effects in vitro of lamivudine (3TC) and other five anti-HBV drugs.The contents of human hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus DNA (HBV DNA) in the culture supernatant of 2.2.15 cell line transfected with hepatitis B virus gene were tested after the six anti-hepatitis B virus drugs were added respectively, and the accordance of different indexes was compared.All six drugs, within a certain range, exercised only weak or no inhibitive effect on extracellular HBsAg and HBeAg secreted by 2.2.15 cell line. Lamivudine and 2 3-dideoxy-3-fluoroguanosine (FLG) significantly inhibited the level of HBV DNA, with the 50% inhibition concentration(IC50) of 0.31 mumol/L and 0.53 mumol/L respectively. Acyclovir (ACV) and interferon-alpha(IFN-alpha) also inhibited the HBV DNA with the IC50 of 0.33 mmol/L and 96.18 U/ml respectively. Phosphonoformate (PFA) and ribavirin (RBV) showed none effect on HBV DNA content even at the maximum non-toxic concentrations.There is not accordance between the expression activities of proteins of HBsAg and HBeAg and the inhibition of HBV DNA level. HBV DNA level better reflexes the inhibitive effect of different drugs and can be used as an important index for evaluation of anti-HBV effect in vitro." @default.
- W2347701360 created "2016-06-24" @default.
- W2347701360 creator A5011986143 @default.
- W2347701360 creator A5067431012 @default.
- W2347701360 date "2001-08-25" @default.
- W2347701360 modified "2023-09-25" @default.
- W2347701360 title "[Anti-hepatitis B virus effects of lamivudine and other five drugs in vitro]." @default.
- W2347701360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11718074" @default.
- W2347701360 hasPublicationYear "2001" @default.
- W2347701360 type Work @default.
- W2347701360 sameAs 2347701360 @default.
- W2347701360 citedByCount "3" @default.
- W2347701360 countsByYear W23477013602017 @default.
- W2347701360 crossrefType "journal-article" @default.
- W2347701360 hasAuthorship W2347701360A5011986143 @default.
- W2347701360 hasAuthorship W2347701360A5067431012 @default.
- W2347701360 hasConcept C153911025 @default.
- W2347701360 hasConcept C159047783 @default.
- W2347701360 hasConcept C185592680 @default.
- W2347701360 hasConcept C2522874641 @default.
- W2347701360 hasConcept C2775940106 @default.
- W2347701360 hasConcept C2776178377 @default.
- W2347701360 hasConcept C2777382497 @default.
- W2347701360 hasConcept C2777410769 @default.
- W2347701360 hasConcept C2777869810 @default.
- W2347701360 hasConcept C2780593183 @default.
- W2347701360 hasConcept C71924100 @default.
- W2347701360 hasConcept C86803240 @default.
- W2347701360 hasConceptScore W2347701360C153911025 @default.
- W2347701360 hasConceptScore W2347701360C159047783 @default.
- W2347701360 hasConceptScore W2347701360C185592680 @default.
- W2347701360 hasConceptScore W2347701360C2522874641 @default.
- W2347701360 hasConceptScore W2347701360C2775940106 @default.
- W2347701360 hasConceptScore W2347701360C2776178377 @default.
- W2347701360 hasConceptScore W2347701360C2777382497 @default.
- W2347701360 hasConceptScore W2347701360C2777410769 @default.
- W2347701360 hasConceptScore W2347701360C2777869810 @default.
- W2347701360 hasConceptScore W2347701360C2780593183 @default.
- W2347701360 hasConceptScore W2347701360C71924100 @default.
- W2347701360 hasConceptScore W2347701360C86803240 @default.
- W2347701360 hasIssue "16" @default.
- W2347701360 hasLocation W23477013601 @default.
- W2347701360 hasOpenAccess W2347701360 @default.
- W2347701360 hasPrimaryLocation W23477013601 @default.
- W2347701360 hasRelatedWork W1556816728 @default.
- W2347701360 hasRelatedWork W1990135901 @default.
- W2347701360 hasRelatedWork W1996263738 @default.
- W2347701360 hasRelatedWork W2056089018 @default.
- W2347701360 hasRelatedWork W2088437131 @default.
- W2347701360 hasRelatedWork W2151970429 @default.
- W2347701360 hasRelatedWork W2382375426 @default.
- W2347701360 hasRelatedWork W2953442664 @default.
- W2347701360 hasRelatedWork W3142514864 @default.
- W2347701360 hasRelatedWork W56769326 @default.
- W2347701360 hasVolume "81" @default.
- W2347701360 isParatext "false" @default.
- W2347701360 isRetracted "false" @default.
- W2347701360 magId "2347701360" @default.
- W2347701360 workType "article" @default.