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- W2347704871 abstract "Objective To study the inhibitory effect of vascular endothelial growth factor(VEGF) on vascular endothelial cell apoptosis induced by oxidized low density lipoprotein(OX-LDL) and its mechanism,and to evaluate the mechanism of VEGF on prevention of restenosis after angioplasty.Methods Human umbilical vein endothelial cells(HUVEC) were divided into control group,OX-LDL-treated group and OX-LDL+VEGF-treated group,the apoptosis of HUVEC was determined by flow cytometry(FCM) and terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling(TUNEL),the expression of Bcl-2 mRNA and Fas mRNA were examined by reverse transcription polymerase chain reaction(RT-PCR).Results Compared with control group and OX-LDL+VEGF-treated group,the apoptosis cell and the expression of Fas mRNA of OX-LDL-treated group were significantly increased.However,the expression of Bcl-2 mRNA was markedly decreased.Conclusion VEGF could inhibit the apoptosis of HUVEC induced by OX-LDL,which may correlated with upregulation Bcl-2 mRNA expression and inhibiting Fas mRNA expression,which offered further theoretical evidence for VEGF on prevention of restenosis after angioplasty." @default.
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- W2347704871 date "2007-01-01" @default.
- W2347704871 modified "2023-09-28" @default.
- W2347704871 title "The Effect of Vascular Endothelial Growth Factor on Vascular Endothelial Cell Apoptosis Induced by OX-LDL and its Mechanism" @default.
- W2347704871 hasPublicationYear "2007" @default.
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