Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347714788> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2347714788 abstract "Objective To investigate the effect of antisense vascular endothelial growth factor (VEGF) gene transfection on the expression of VEGF in retinoblastoma cell by means of adeno-associated virus-mediated vector in vitro and to explore a new gene therapy strategy for retinoblastoma.Methods A small amounts of antisense VEGF genes were transfected into retinoblastoma cell line HXO-Rb 44,immunohistochemical image analysis and semi-quantitive RT-PCR techniques were used to evaluate the expression of VEGF in retinoblastoma cell line HXO-Rb 44.Results Immunohistochemical image analysis showed that the staining degree of VEGF protein decreased significantly after antisense VEGF genes transferred (the gray numerical value:17286±15.56 vs 243.41±18.62,P=0.007).Semi-quantitive RT-PCR measurements showed that the expression of VEGF mRNA decreased significantly after transfection (relative expression levels:0.952±0.02 vs 0.428±005,P=0000).Conclusion It is suggested that the antisense VEGF genes have an inhibitory effect on the expression of VEGF in HXO-Rb 44 cell in vitro and the results provided the experimental evidence for the further treatment of retinoblastoma." @default.
- W2347714788 created "2016-06-24" @default.
- W2347714788 creator A5016261953 @default.
- W2347714788 creator A5028343642 @default.
- W2347714788 creator A5065076327 @default.
- W2347714788 date "2005-01-01" @default.
- W2347714788 modified "2023-09-23" @default.
- W2347714788 title "Effect of antisense VEGF gene transfection on the expression of VEGF in retinoblastoma cells in vitro" @default.
- W2347714788 hasPublicationYear "2005" @default.
- W2347714788 type Work @default.
- W2347714788 sameAs 2347714788 @default.
- W2347714788 citedByCount "0" @default.
- W2347714788 crossrefType "journal-article" @default.
- W2347714788 hasAuthorship W2347714788A5016261953 @default.
- W2347714788 hasAuthorship W2347714788A5028343642 @default.
- W2347714788 hasAuthorship W2347714788A5065076327 @default.
- W2347714788 hasConcept C104317684 @default.
- W2347714788 hasConcept C111599444 @default.
- W2347714788 hasConcept C146285616 @default.
- W2347714788 hasConcept C150194340 @default.
- W2347714788 hasConcept C153911025 @default.
- W2347714788 hasConcept C167734588 @default.
- W2347714788 hasConcept C202751555 @default.
- W2347714788 hasConcept C203014093 @default.
- W2347714788 hasConcept C204232928 @default.
- W2347714788 hasConcept C2776577112 @default.
- W2347714788 hasConcept C2777025900 @default.
- W2347714788 hasConcept C502942594 @default.
- W2347714788 hasConcept C54009773 @default.
- W2347714788 hasConcept C54355233 @default.
- W2347714788 hasConcept C55493867 @default.
- W2347714788 hasConcept C81885089 @default.
- W2347714788 hasConcept C86803240 @default.
- W2347714788 hasConceptScore W2347714788C104317684 @default.
- W2347714788 hasConceptScore W2347714788C111599444 @default.
- W2347714788 hasConceptScore W2347714788C146285616 @default.
- W2347714788 hasConceptScore W2347714788C150194340 @default.
- W2347714788 hasConceptScore W2347714788C153911025 @default.
- W2347714788 hasConceptScore W2347714788C167734588 @default.
- W2347714788 hasConceptScore W2347714788C202751555 @default.
- W2347714788 hasConceptScore W2347714788C203014093 @default.
- W2347714788 hasConceptScore W2347714788C204232928 @default.
- W2347714788 hasConceptScore W2347714788C2776577112 @default.
- W2347714788 hasConceptScore W2347714788C2777025900 @default.
- W2347714788 hasConceptScore W2347714788C502942594 @default.
- W2347714788 hasConceptScore W2347714788C54009773 @default.
- W2347714788 hasConceptScore W2347714788C54355233 @default.
- W2347714788 hasConceptScore W2347714788C55493867 @default.
- W2347714788 hasConceptScore W2347714788C81885089 @default.
- W2347714788 hasConceptScore W2347714788C86803240 @default.
- W2347714788 hasOpenAccess W2347714788 @default.
- W2347714788 hasRelatedWork W1956917697 @default.
- W2347714788 hasRelatedWork W2060645782 @default.
- W2347714788 hasRelatedWork W2367468890 @default.
- W2347714788 hasRelatedWork W2375046046 @default.
- W2347714788 hasRelatedWork W2380193094 @default.
- W2347714788 hasRelatedWork W2395718301 @default.
- W2347714788 hasRelatedWork W2396459967 @default.
- W2347714788 hasRelatedWork W2410884867 @default.
- W2347714788 hasRelatedWork W2413989849 @default.
- W2347714788 hasRelatedWork W2414381150 @default.
- W2347714788 hasRelatedWork W2587815235 @default.
- W2347714788 hasRelatedWork W3030166710 @default.
- W2347714788 hasRelatedWork W3032592835 @default.
- W2347714788 hasRelatedWork W3032630269 @default.
- W2347714788 hasRelatedWork W3032817002 @default.
- W2347714788 hasRelatedWork W3145678465 @default.
- W2347714788 hasRelatedWork W3147302798 @default.
- W2347714788 hasRelatedWork W3151777132 @default.
- W2347714788 hasRelatedWork W3152200444 @default.
- W2347714788 hasRelatedWork W3029640330 @default.
- W2347714788 isParatext "false" @default.
- W2347714788 isRetracted "false" @default.
- W2347714788 magId "2347714788" @default.
- W2347714788 workType "article" @default.