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- W2347718847 abstract "Purpose To investigate the expression of ADAM23 and alphavbeta 3(αvβ3)in non-small cell lung cancer(NSCLC).Methods The expression of ADAM23 and αvβ3's protein and mRNA in 52 specimens of NSCLC and its adjacent to carcinoma and 8 specimens of benign lung tissues were detected using immunohistochemmistry(IHC)and reverse transcription polymerase chain reaction(RT-PCR).Results The positive rate of ADAM23 protein was significantly lower in NSCLC than that of tissues adjacent to carcinoma and benign lung tissues(38.5% vs 86.5% and 87.5%,P0.05),whereas the positive rate of αvβ3 protein was significantly higher in NSCLC than that of tissues adjacent to carcinoma and benign lung tissues(80.8% vs 26.9% and 37.5%,P0.05).ADAM23 expression had no correlation with patients'age,sex,tumor size and histological type but markedly related to tumor differentiation degree,lymph node metastasis and clinical stage in NSCLC;αvβ3 expression had no correlation with patients'age,sex,histological type and tumor differentiation degree,but markedly related to tumor size,lymph node metastasis and clinical stage in NSCLC.The result of RT-PCR showed that there were no significantly different expression of ADAM23 in NSCLC and tissues adjacent to carcinoma,together with benign lung tissues in NSCLC;whereas the expression of αv、β3 was significantly higher than tissues adjacent to carcinoma and benign lung tissues.The positive rates between ADAM23 and αvβ3 were correlated.(χ2=9.026,r=-0.417,P0.05).Conclusion ADAM23 is lower-expressed while αvβ3 is over-expressed in NSCLC.They may play an important and cooperative role in invasion and metastasis of NSCLC." @default.
- W2347718847 created "2016-06-24" @default.
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- W2347718847 date "2010-01-01" @default.
- W2347718847 modified "2023-09-27" @default.
- W2347718847 title "Expression of ADAM23 and αvβ3 in non-small cell lung cancer and its clinicopathologic significance" @default.
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