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- W2347722308 abstract "Objective To observe the effect of hepatitis C virus(HCV)superinfection on the efficacy of Tailai polypeptide(anti hepatitis B placental polypeptide)treatment of patients with chronic hepatitis B(CHB)and explore its prevention and treatment countermeasures Methods Ninety six, 48 CHB patients with and without HCV superinfection were enrolled in this study, respectively All patients were treated with Tailai polypeptide for 4 months Forty eight, 48 CHB patients with and without HCV superinfection were given Tailai polypeptide 4 ml im qd (the routine dose group), whereas 48 CHB patients with HCV superinfection were given it 6 ml im bid (the high dose group) The CHB patients with and without HCV superinfection were comparable in their age, sex, course of disease and liver lesions and they had serum positive of HBsAg, HBeAg, HBV DNA and ALT abnormality Then the rate of ALT normality, HBeAg, HBV DNA disappearance and the amount changes of serum HBV DNA at the completion of therapy from CHB patients with HCV superinfection were compared with those of patients without HCV superinfection Results The rate of ALT normality, HBeAg, HBV DNA disappearance and the amount changes of serum HBV DNA in CHB patients with HCV superinfection were lower than those of patients without HCV superinfection in the routine dose group( P 0.05), whereas the results of the above mentioned parameters from the high dose group were higher than those of the routine dose group in CHB patients with HCV superinfection( P 0.05) Conclusion HCV superinfection impairs the efficacy of Tailai polypeptide treatment of patients with CHB High dose Tailai polypeptide is a well treatment countermeasure for CHB patients with HCV superinfection It is necessary for patients with CHB to avoid receiving the blood and blood products transfusion as possible as for preventing HCV superinfection" @default.
- W2347722308 created "2016-06-24" @default.
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- W2347722308 date "2002-01-01" @default.
- W2347722308 modified "2023-09-25" @default.
- W2347722308 title "Effects of Hepatitis C Virus Superinfection on Efficacy of Tailai Polypeptide (Antihepatitis B Placental Polypeptide) Treatment of Patients with Chronic Hepatitis B and its Prevention and Treatment Countermeasures" @default.
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