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- W2347729643 abstract "Objective To establish an animal model which can be used to study the regenerative mechanism of damaged liver which suffered partial hepatectomy.Materials 7 of total 35 male SD rats were used to observe the lobes of liver and to measure the weight of each lobe. The others were randomly divided into 4 groups: CCL4 + 35% hepatectomy;CCL4 + 65% hepatectomy;CCL4 + 80% hepatectomy;normal control.The survival rate was recorded 1 day after operation. At the 3rd and 7th day,blood was collected by puncturing orbital vein plexus to determine liver function (ALT/AST/ALB), and liver tissues were harvested to be examined by histological method.Results (1) Liver of rats was (4.50±0.76)% of body weight.It consisted of 7 lobes, left lateral lobe,left medial lobe,medial lobe,right lobe,caudate lobe,anterior and posterior discs,which comprised (36.25±2.96)%, (9.63±1.30)%, (20.00±1.31)%, (16.13±2.80)%, (6.38±1.19)%, (5.00±0.71)%, (6.80±2.17)% of the liver weight respectively;(2) The survival rate of 35%,65%,80% hepatecotomy was 100% , 42.9% , 0% respectively;(3) Liver function was significantly damaged and livertissues showed acute pathological changes 3 and 7 days after operation.Conclusions Rat model of partial hepatectomy following acute liver injury induced by CCL4 is a feasible approach to study the regenerative mechanism of damaged liver suffered partial hepatectomy.The appropriate range being excised is about 35%." @default.
- W2347729643 created "2016-06-24" @default.
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- W2347729643 date "2009-01-01" @default.
- W2347729643 modified "2023-09-25" @default.
- W2347729643 title "A Combined Liver Injury Rat Model:Partial Hepatectomy after Acute Liver Injury Induced by Carbon Tetrachloride" @default.
- W2347729643 hasPublicationYear "2009" @default.
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