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- W2347730633 abstract "OBJECTIVE To establish a HPLC-UV method for the determination of zidovudine in human plasma,and to investigate the pharmacokinetics of zidovudine in 12 volunteers.METHODS The chromatographic separation was achieved on a Symmetry C_ 18 (4.6 mm×250 mm, 5 μm).The mobile phase was acetonitrile-waters (25∶75).The detection wavelength was at 265 nm.The internal standard was tinidazole,the plasma samples were extracted with solid phase extraction.RESULTS A good linearity was obtained from 20 to 4 000 μg·L~ -1 in plasma with a correlation coefficient of 0.999 9.The plasma extraction recovery was above 90%.The within-day and between-day RSDs were less than 3%.The pharamacokinetic analysis of zidovudine in 12 volunteers after oral administration of 400 mg zidovudine capsules was studied .It was found to be fitted to a two-compartment open model and its pharmacokinetic parameters were as follows:t_ max (0.73±0.13)h,ρ_ max (2 234.50±853.87)μg·L~ -1 ,AUC_0-t (3 358.75±572.97)μg·h·L~ -1 ,t_1/2β (1.43±0.49)h.CONCLUSION The pharmacokinetics of zidovudine in human provide a useful index for clinical trial." @default.
- W2347730633 created "2016-06-24" @default.
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- W2347730633 date "2007-01-01" @default.
- W2347730633 modified "2023-09-25" @default.
- W2347730633 title "Determination of Zidovudine in Human Plasma by HPLC:Application to Its Pharmacokinetics" @default.
- W2347730633 hasPublicationYear "2007" @default.
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