Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347737161> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2347737161 abstract "Objective:To observe the effects of heat shock factor 1(HSF1)polymerization on the LPS-induced febrile reaction in rabbits and study its relationship with cAMP content,so as to investigate whether HSF1 plays a role in the fever limiting function and the possible mechanisms.Methods:Seventy rabbits were randomly divided into 4 groups:(1)Normal control group(N),injection of ethanol in the lateral venericle;(2)Quereetin group(Q),injection of quercetin and ethanol solution(2.5 μmol/L);(3)Lipopolysaccharide group(L),LPS(0.5 μg/kg)was injected 10 min after injection of ethanolt(4)Quercetin plus LPS group(Q+L),LPS was injceted 10 min after injection of quercetin plus ethanol(2.5 μmol/L).The polymerization of HSF1 was induced by reproducing LPS-induced febrile reaction model in rabbits to assess the influence of polymerized HSF1 on LPS-induced febrile reaction.The content of cAMP in the hypothalamus was measured by radioimmunoassay.The expression of HSF1 and HSP70 protein in the hypothalamus was detected by Western blotting.Results:The difference between basal temperature and temperatures of defined time points AT(240-360 min)of Q+L group was significantly higher than that of L group(P0.05);TRI6 was 8.32±0.63 in Q+L group,significantly higher than that of L group(P0.05);and the contents of cAMP of Q+L group at all time points were significantly higher than those of the L group(P0.01).Polymeric HSF1 content started to increase at 60 min after LPS injection and obviously increased when the body temperature reached the peak(180 min,being 1.77 folds that of the control level);then with the increase of HSF1 trimerization,the body temperature beganto decrease.When pretreatment with quercetin was performed to inhibit polymerization of HSF,the levels of HSF1 trimerization at 60 min,180 min,240 min,and 360 min in Q+L group were significantly lower than those in the corresponding L group(all P0.05);meanwhile,the expression of HSP70 was decreased,the content of cAMP was increased,the febrile reaction was intensified and the time course of the febrile reaction was extended.Conclusion:Polymeric HSF1 can inhibit the LPS-induced febrile reaction,which is probably related to the down-regulation of cAMP content in the hypothalamus." @default.
- W2347737161 created "2016-06-24" @default.
- W2347737161 creator A5069941190 @default.
- W2347737161 date "2008-01-01" @default.
- W2347737161 modified "2023-09-24" @default.
- W2347737161 title "Fever-induced polymerization of heat shock factor 1 influences body temperature and cAMP content in hypothalamus of rabbits" @default.
- W2347737161 hasPublicationYear "2008" @default.
- W2347737161 type Work @default.
- W2347737161 sameAs 2347737161 @default.
- W2347737161 citedByCount "0" @default.
- W2347737161 crossrefType "journal-article" @default.
- W2347737161 hasAuthorship W2347737161A5069941190 @default.
- W2347737161 hasConcept C104317684 @default.
- W2347737161 hasConcept C126322002 @default.
- W2347737161 hasConcept C134018914 @default.
- W2347737161 hasConcept C176685330 @default.
- W2347737161 hasConcept C178790620 @default.
- W2347737161 hasConcept C185592680 @default.
- W2347737161 hasConcept C205260736 @default.
- W2347737161 hasConcept C24998067 @default.
- W2347737161 hasConcept C2776667301 @default.
- W2347737161 hasConcept C2777003273 @default.
- W2347737161 hasConcept C2778004101 @default.
- W2347737161 hasConcept C2778754761 @default.
- W2347737161 hasConcept C2780161600 @default.
- W2347737161 hasConcept C2781263971 @default.
- W2347737161 hasConcept C44228677 @default.
- W2347737161 hasConcept C521977710 @default.
- W2347737161 hasConcept C55493867 @default.
- W2347737161 hasConcept C68991219 @default.
- W2347737161 hasConcept C71924100 @default.
- W2347737161 hasConceptScore W2347737161C104317684 @default.
- W2347737161 hasConceptScore W2347737161C126322002 @default.
- W2347737161 hasConceptScore W2347737161C134018914 @default.
- W2347737161 hasConceptScore W2347737161C176685330 @default.
- W2347737161 hasConceptScore W2347737161C178790620 @default.
- W2347737161 hasConceptScore W2347737161C185592680 @default.
- W2347737161 hasConceptScore W2347737161C205260736 @default.
- W2347737161 hasConceptScore W2347737161C24998067 @default.
- W2347737161 hasConceptScore W2347737161C2776667301 @default.
- W2347737161 hasConceptScore W2347737161C2777003273 @default.
- W2347737161 hasConceptScore W2347737161C2778004101 @default.
- W2347737161 hasConceptScore W2347737161C2778754761 @default.
- W2347737161 hasConceptScore W2347737161C2780161600 @default.
- W2347737161 hasConceptScore W2347737161C2781263971 @default.
- W2347737161 hasConceptScore W2347737161C44228677 @default.
- W2347737161 hasConceptScore W2347737161C521977710 @default.
- W2347737161 hasConceptScore W2347737161C55493867 @default.
- W2347737161 hasConceptScore W2347737161C68991219 @default.
- W2347737161 hasConceptScore W2347737161C71924100 @default.
- W2347737161 hasLocation W23477371611 @default.
- W2347737161 hasOpenAccess W2347737161 @default.
- W2347737161 hasPrimaryLocation W23477371611 @default.
- W2347737161 hasRelatedWork W1974256277 @default.
- W2347737161 hasRelatedWork W1978725428 @default.
- W2347737161 hasRelatedWork W2001704727 @default.
- W2347737161 hasRelatedWork W2040740070 @default.
- W2347737161 hasRelatedWork W2054470611 @default.
- W2347737161 hasRelatedWork W2056325072 @default.
- W2347737161 hasRelatedWork W2059837704 @default.
- W2347737161 hasRelatedWork W2281379437 @default.
- W2347737161 hasRelatedWork W2358170016 @default.
- W2347737161 hasRelatedWork W2360739565 @default.
- W2347737161 hasRelatedWork W2364546005 @default.
- W2347737161 hasRelatedWork W2365062124 @default.
- W2347737161 hasRelatedWork W2369111061 @default.
- W2347737161 hasRelatedWork W2370995516 @default.
- W2347737161 hasRelatedWork W2374625575 @default.
- W2347737161 hasRelatedWork W2379423032 @default.
- W2347737161 hasRelatedWork W2379456694 @default.
- W2347737161 hasRelatedWork W2384249373 @default.
- W2347737161 hasRelatedWork W2391989594 @default.
- W2347737161 hasRelatedWork W2400277591 @default.
- W2347737161 isParatext "false" @default.
- W2347737161 isRetracted "false" @default.
- W2347737161 magId "2347737161" @default.
- W2347737161 workType "article" @default.