Matches in SemOpenAlex for { <https://semopenalex.org/work/W2347738400> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2347738400 abstract "Objective To investigate the protective effect and mechanism of nortryptyline on oxygen-glucose deprivation(OGD)-induced primary cortical neuronal death.Methods In vitro cultured primary cortical neurons were induced by OGD with nortryptyline in different concentrations(1.0,2.5,5.0,10.0 μmol/L),or without nortryptyline pretreatment.Then the neuronal activity and survival rate were determined by MTT,immunocytochemical staining and trypan blue staining.Also,release amounts of cytochrome c,Smac/Diablo and apoptosis-inducing factor(AIF) were determined by Western blot.Results Nortryptyline significantly improved the growth condition and survival rate of primary cortical neurons,and inhibited cytochrome c,Smac/Diablo and AIF release after OGD injury.Conclusion Nortryptyline plays a neuroprotective role in cortical neuronal death induced by OGD,via the inhibition of cytochrome c,Smac/Diablo and AIF release." @default.
- W2347738400 created "2016-06-24" @default.
- W2347738400 creator A5067894822 @default.
- W2347738400 date "2011-01-01" @default.
- W2347738400 modified "2023-09-23" @default.
- W2347738400 title "Protective effect of tricyclic antidepressant nortryptyline of cortical neurons on rats with OGD-induced injury and its mechanism" @default.
- W2347738400 hasPublicationYear "2011" @default.
- W2347738400 type Work @default.
- W2347738400 sameAs 2347738400 @default.
- W2347738400 citedByCount "0" @default.
- W2347738400 crossrefType "journal-article" @default.
- W2347738400 hasAuthorship W2347738400A5067894822 @default.
- W2347738400 hasConcept C104317684 @default.
- W2347738400 hasConcept C185592680 @default.
- W2347738400 hasConcept C190283241 @default.
- W2347738400 hasConcept C25498285 @default.
- W2347738400 hasConcept C2776415932 @default.
- W2347738400 hasConcept C2780070996 @default.
- W2347738400 hasConcept C29311851 @default.
- W2347738400 hasConcept C2983650178 @default.
- W2347738400 hasConcept C48349386 @default.
- W2347738400 hasConcept C55493867 @default.
- W2347738400 hasConcept C86803240 @default.
- W2347738400 hasConcept C95444343 @default.
- W2347738400 hasConcept C98274493 @default.
- W2347738400 hasConceptScore W2347738400C104317684 @default.
- W2347738400 hasConceptScore W2347738400C185592680 @default.
- W2347738400 hasConceptScore W2347738400C190283241 @default.
- W2347738400 hasConceptScore W2347738400C25498285 @default.
- W2347738400 hasConceptScore W2347738400C2776415932 @default.
- W2347738400 hasConceptScore W2347738400C2780070996 @default.
- W2347738400 hasConceptScore W2347738400C29311851 @default.
- W2347738400 hasConceptScore W2347738400C2983650178 @default.
- W2347738400 hasConceptScore W2347738400C48349386 @default.
- W2347738400 hasConceptScore W2347738400C55493867 @default.
- W2347738400 hasConceptScore W2347738400C86803240 @default.
- W2347738400 hasConceptScore W2347738400C95444343 @default.
- W2347738400 hasConceptScore W2347738400C98274493 @default.
- W2347738400 hasLocation W23477384001 @default.
- W2347738400 hasOpenAccess W2347738400 @default.
- W2347738400 hasPrimaryLocation W23477384001 @default.
- W2347738400 hasRelatedWork W1903028880 @default.
- W2347738400 hasRelatedWork W2018231751 @default.
- W2347738400 hasRelatedWork W2020182719 @default.
- W2347738400 hasRelatedWork W2029591805 @default.
- W2347738400 hasRelatedWork W2034642841 @default.
- W2347738400 hasRelatedWork W2086109195 @default.
- W2347738400 hasRelatedWork W2113097839 @default.
- W2347738400 hasRelatedWork W2259560048 @default.
- W2347738400 hasRelatedWork W2272891224 @default.
- W2347738400 hasRelatedWork W2364392633 @default.
- W2347738400 hasRelatedWork W2369220819 @default.
- W2347738400 hasRelatedWork W2372121187 @default.
- W2347738400 hasRelatedWork W2385205518 @default.
- W2347738400 hasRelatedWork W2461028299 @default.
- W2347738400 hasRelatedWork W2555514253 @default.
- W2347738400 hasRelatedWork W2590700807 @default.
- W2347738400 hasRelatedWork W2612330109 @default.
- W2347738400 hasRelatedWork W2883973473 @default.
- W2347738400 hasRelatedWork W3143970915 @default.
- W2347738400 hasRelatedWork W3209598241 @default.
- W2347738400 isParatext "false" @default.
- W2347738400 isRetracted "false" @default.
- W2347738400 magId "2347738400" @default.
- W2347738400 workType "article" @default.