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- W2347740384 abstract "Objective:To explore the effect of adenosine triphosphate-magnesium chloride(ATP-MgCl2) on hyperoxia induced lung injury of neonatal rats.Methods:120 Wistar rats aged 2 days old whose body weight was 5~10 grams were selected and divided into air control group,hyperoxia model group and ATP-MgCl2 treatment group randomly,40 rats in each group.The neonatal rat models of hyperoxia were established,the neonatal rats in ATP-MgCl2 treatment group were treated with intraperitoneal injection of ATP-MgCl2(45 mg/kg) on the second day;the neonatal rats in air control group and hyperoxia model group were treated with intraperitoneal injection of normal saline of the same dose.On the third,seventh and fourteenth day,10 rats in each group were executed,then lung tissue samples were obtained,the pathological changes of lung tissues were observed under light microscope,immunohistochemical staining was used to observe the expression levels of tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1) and vimentin in lung tissues.Results:The expression levels of TNF-α,TGF-β1 and vimentin in hyperoxia model group were significantly higher than those in air control group(P0.01).The expression levels of TNF-α,TGF-β1 and vimentin in ATP-MgCl2 treatment group were significantly lower than those in hyperoxia model group(P0.05).Conclusion:ATP-MgCl2 can protect hyperoxia induced lung injury of neonatal rats,which has a certain preventive effect on bronchopulmonary dysplasia." @default.
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- W2347740384 date "2011-01-01" @default.
- W2347740384 modified "2023-09-25" @default.
- W2347740384 title "Effect of adenosine triphosphate-magnesium chloride on hyperoxia induced lung injury of neonatal rats" @default.
- W2347740384 hasPublicationYear "2011" @default.
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