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- W2347747414 abstract "Objective To study whether Saffron has liver toxicity,and the possible mechanism of liver injury.Methods Male Wistar rats were randomly divided into 5 groups,15 rats in each group.Rats in group A,B,C,D were fed with high,middle,low dosage Saffron liquid(80 mg/mL,40 mg/mL,20 mg/mL) respectively,0.9% NaCl 1 mL per 100 g once a day for 6 weeks.Rats in group E were fed with 60%alcohol 2 mL,per 100 g twice a day for 6 weeks.The rat's ordinary circumstances,weight and blood biochemistry were observed in 2th,6th week,and the microscopic examination was done in the end of the 6th week.Results The serum alkaline phosphatase activities went up along with the feeding time in high dosage group.The values were(190.5±37.8)U/mL,(253.5±46.6 U)/mL in 2th,6th weekend respectively.There was significant difference compared with group D in 6th week(P0.05).Microscope results showed that hepatocyte in group A swelled with the buildup of little fatty drop was in disorder,hepatocyte in group B was in disorder,hepatocyte in group C was normal.Conclution High dosage Saffron has hepatotoxicity.Mitochondria dysfunction might be possible mechanism." @default.
- W2347747414 created "2016-06-24" @default.
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- W2347747414 date "2010-01-01" @default.
- W2347747414 modified "2023-09-23" @default.
- W2347747414 title "Experimental study of Saffron hepaotoxicity in rats" @default.
- W2347747414 hasPublicationYear "2010" @default.
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