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- W2347749122 abstract "OBJECTIVE: To study pharmacokinetics profiles of lansoprazole enteric-coated tablets in human bodies.METHODS: All the 8 healthy volunteers were administered with a single oral dose of 30mg lansoprazole enteric-coated tablets,whose blood samples were determined by HPLC-UV after being pretreated with the internal standard(omeprazole).RESULTS: The linear range of lansoprazole was 20.00～ 2 000.00ng· mL-1(r=0.999 9).Both intraday and inter-day RSD were less than 10%.The main pharmacokinetic parameters were as follows: Cmax was(876.14± 278.11) ng· mL-1,tmax was(3.81± 0.70) h;t1/2 was(1.68± 0.70) h;AUC0～ t was(2 925.04± 1 110.88) ng· h· mL-1,AUC0～ ∞ was(3 072.88± 1 230.40) ng· h· mL-1.CONCLUSION: This method is simple,sensitive and without interference of impurity peaks,and the pharmacokinetic parameters obtained can serve as references for the clinical application of lansoprazole." @default.
- W2347749122 created "2016-06-24" @default.
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- W2347749122 date "2007-01-01" @default.
- W2347749122 modified "2023-09-23" @default.
- W2347749122 title "Pharmacokinetics of Lansoprazole Enteric-coated Tablets in Healthy Human Bodies" @default.
- W2347749122 hasPublicationYear "2007" @default.
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