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- W2347766328 abstract "OBJECTIVE To study the effects of Danshi Liuhao decoction on the expression of CCKAR,5-HT3aR in the bile pigment with calculus,and provide experimental basis for the clinical use of Danshi Liuhao decoction.METHODS Forty guinea pigs were randomly divided into normal group(n=10),untreated group(n=15)and Danshi Liuhao treated group(n=15). Calculus was induced in guinea pigs of the latter two groups by feeding them with a special diet.During one month treatment period,the guinea pigs of Danshi Liuhao group were intragastrically administered with Danshi Liuhao decoction at a dose of 7.7 g·kg-1 per day,then the animals were sacrificed and sampled to calculate the incidences of stone formation.CCKAR,5-HT3aR mRNA and protein expression were also analyzed at the end of diet treatment.RESULTS Stone formation rate was 91.67%in the untreated group,which was significantly higher than that in the blank group(10.00%)and in the Danshi Liuhao decoction treated group(26.67%).The results of RT-PCR indicated that the expression level of CCKAR,5-HT3aR of untreated group was significantly lower than the blank group,while the Danshi Liuhao decoction treated group significantly higher than the blank group and untreated group(P0.05).Immunohistochemical result of 5-HT3aR protein showed that the amount of 5-HT3aR protein in untreated group was much lower than that in the blank group,while much higher in the Danshi Liuhao decoction group than that in the untreated group(P0.05).But the immunohistochemical results showed that the amount of CCKAR protein of untreated group was lower than that of the blank group,while higher in the Danshi Liuhao decoction group than that in the untreated group,but the difference had no statistical significance(P0.05).CONCLUSION Danshi Liuhao decoction significantly affected the mRNA and protein expression of CCKAR,5-HT3aR in guinea pig bearing bile pigment stones.Its therapeutic effect on bile pigment calculus was achieved partly by increasing the expression of CCKAR and 5-HT3aR." @default.
- W2347766328 created "2016-06-24" @default.
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- W2347766328 date "2014-01-01" @default.
- W2347766328 modified "2023-09-26" @default.
- W2347766328 title "Effects of Danshi Liuhao decoction on the expression of CCKAR,5-HT3aR in guinea pig bearing bile pigment stones" @default.
- W2347766328 hasPublicationYear "2014" @default.
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