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- W2347766922 abstract "Aim:Synthetic peptides corresponding to the sequences 60～70(Es-2) of human endostatin have been found to inhibit basic fibroblast growth factor-induced directional migration and tubular morphogenesis of microvascular endothelial cells.Accordingly,the peptide induced the loss of focal adhesions and actin stress fibers in these cells.In this study,we aimed to investigate the effects of endostatin-derived peptide Es-2 on angiogenesis and the growth of tumor in vivo.Methods:A peptide of 25 amino acids including the sequences 60～70 of endostatin was synthesized,MTT and chick chorioallantoic membrane(CAM)assay was conducted.A treatment of mice bearing B16F10 melanoma with Es-2 was also carried out.Results:In CAM,Es-2 was found to be fully biologically active in the angiogenesis assays and it even showed greater potency and efficacy than full-length human endostatin.Compared with the negative control group,Es-2 could significantly reduce the growth of melanoma in vivo(P0.05).Conclusion:Synthetic peptide Es-2 has the promising in the application of clinical therapy." @default.
- W2347766922 created "2016-06-24" @default.
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- W2347766922 date "2006-01-01" @default.
- W2347766922 modified "2023-09-26" @default.
- W2347766922 title "Biological activity of human endostatin-derived synthetic peptide——Es-2" @default.
- W2347766922 hasPublicationYear "2006" @default.
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