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- W2347774735 abstract "Objective To explore the roles of lipolysis and hormone sensitive lipase (HSL) of pancreatic islets in giucolipotoxicity by observing the changes of triglyceride (TG),lipolysis and HSL in the islets of diabetes rats.Methods Diabetes rats (DM) were induced by feeding the fat-rich food and injecting the streptozotocin.Normal rats (NC) and rats fed with fat-rich food (HF) were provided.Blood glucose,plasma insulin,plasma lipids,TG and expression of HSL gene and protein in the islets were measured.The measured free fatly acid released from the islets represented the activity of lipolysis Results The blood glucose showed no difference between HF group and NC group,but plasma insulin and plasma lipids in HF group rats were significantly elevated as compared with NC group(P0.05 orP 0.01).The blood glucose and plasma lipids in DM group rats were significantly increased(P0.05 orP 0.01).The plasma insulin in DM group rats was similar to that in NC group.Compared with NC group, TG in the islets of rat in HF group was significantly increased(P0.05),TG accumulation in the islets of diabetes rats was as 2.15 times as that of NC group.At the same time,the lipolysis and the expression of HSL in HF and DM group markedly increased(P 0.05 orP0.01).Conclusions The increase of lipolysis and HSL activity in the islets of diabetes rats could be a compensation to alleviate the TG accumulation and to keep the metabolism balance of glucose and lipids,and may protect against fatty acidinduced islet dysfunction." @default.
- W2347774735 created "2016-06-24" @default.
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- W2347774735 date "2010-01-01" @default.
- W2347774735 modified "2023-09-26" @default.
- W2347774735 title "The changes and significance of lipolysis in pancreatic islets of diabetes rats" @default.
- W2347774735 hasPublicationYear "2010" @default.
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