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- W2347777144 abstract "Objective:To detect the expression of estrogen,progesterone and vascular endothelial growth factor(VEGF)in patients with preeclampsia,and explore the pathogenesis of preeclampsia.Methods:Fifty patients with preeclampsia were recruited as observation group;meanwhile,50 normal pregnant women were selected as control group in our hospital from May 2013 to May 2014.The levels and expression of estrogen(E2),progesterone(P)and VEGF were detected by chemical immunofluorescent and immunohistochemical method respectively.Morphological changes were observed by HE methods.Results:Estradiol levels in the observation group(40.81±6.88pmol/L)were significantly lower than those in the control group(79.20±7.23pmol/L)(P0.05),while progesterone levels in the observation group(595.77±66.59nmol/L)were significantly higher than those in the control group(328.40±59.56nmol/L(P0.05).Therefore,E2/P ratio in the observation group was significantly lower than those in the control group(P0.05).The positive expression rate of VEGF protein in the observation group(96%)was also significantly higher than that in the control group(46%)(P 0.05).The villous morphology was intact,and stroma and blood vessels were normal in placenta of the control group.However,many abnormal phenomena were found in the placenta of the observation group,which included irregular villous morphology,vascular damage,reduction and congestion,stromal edema and hyperplasia.Conclusions:Declined estrogen and elevated progesterone levels,and up-regulated expression of VEGF were found in patients with preeclampsia.The changes of hormone levels and injury of vascular endothelial function could lead to the occurrence of preeclampsia." @default.
- W2347777144 created "2016-06-24" @default.
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- W2347777144 date "2015-01-01" @default.
- W2347777144 modified "2023-09-23" @default.
- W2347777144 title "Expressions of estrogen,progesterone and vascular endothelial growth factor in placenta of patients with preeclampsia" @default.
- W2347777144 hasPublicationYear "2015" @default.
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