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- W2347778041 abstract "AIM: This study was to utilize cholinergic antagonists t o examine choli nergic pathway of soman-induced hypothermia. METHODS: Colonic temper ature was mea sured at 60 min intervals with digital thermometer. Effect of peripheral muscar inic antagonist, methylscopolamine and central muscairnic antagonist, scopolamin e on soman-induced hypothermia were observed in the rats. RESULTS: Administration of the soman (60 μg·kg -1 , sc) led to a rapid reduction in body temperature. Administration of scopolamine (1 mg·kg -1 , ip) marke dly blocked the hypothermic effec t of soman but administration of methyl scopolamine (1 mg·kg -1 , ip) had n o effect on the hypothermia. CONCLUSION: The data indicate tha t soman-induced hypothermia is mediated primarily through a central muscairnic pathway." @default.
- W2347778041 created "2016-06-24" @default.
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- W2347778041 date "2004-01-01" @default.
- W2347778041 modified "2023-09-24" @default.
- W2347778041 title "Effect of cholinergic antagonist on soman-induced hypothermia in the rat" @default.
- W2347778041 hasPublicationYear "2004" @default.
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