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- W2347792160 abstract "For many patients with severe chronic anemia,regular blood transfusion is the important lifesaving therapy available.Long-term blood transfusions will unavoidably and invariably produce accumulation of iron(iron overload),and thereby induced iron toxicity.Transfusional hemosiderosis,particularly in the liver or heart,can cause considerable morbidity that may be fatal eventually.Traditionally,iron chelating agents include deferiprone and deferoxamine,but they are not the satisfied treatment choice due to their side effects or non-convenience for administration.Deferasirox,a rationally-designed oral iron chelator,is validated as defined by several phase II trials.Moreover,a pivotal phase III trial revealed that its efficacy is similar to that of deferoxamine in transfusion-dependent patients.Recently reported results from the large,prospective,multicenter EPIC study confirmed its efficacy,and in this study deferasirox was also found to be capable of removing iron from the heart in patients with β-thalassemia and myocardial hemosiderosis.This review summarized the morbidity,mortality,and clinical features of iron overload,and introduced the advantages of the new chelator deferasirox over traditional agents." @default.
- W2347792160 created "2016-06-24" @default.
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- W2347792160 date "2011-01-01" @default.
- W2347792160 modified "2023-09-23" @default.
- W2347792160 title "Overview of iron overload and the new iron chelator deferasirox" @default.
- W2347792160 hasPublicationYear "2011" @default.
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