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- W2347808618 abstract "Objective To evaluate the safety of long-term anti-platelet therapy of combined aspirin and clopidogrel and its inhibitory effect on platelet aggregation after implanting drug-eluting stents.Methods We enrolled a total of 117 patients with coronary heart disease(CHD) who were treated with combined aspirin and clopidogrel after percutaneous coronary intervention(PCI) from 2005-1 to 2006-9.Analysis was performed on the effects of long-term combined anti-platelet therapy on platelet aggregation,leukocytes and platelet counts,and on incidence of complications such as bleeding and skin rash.Results Out of 117 CHD patients who received combined aspirin and clopidigrel treatment after PCI,114 completed follow-up,of whom 81 were male and 43 were female with a mean age of 54.2±12.5.Compared with pre-treatment period,the patients' platelet aggregation and platelet counts decreased significantly one month after treatment,the difference between them was significant(P0.05);platelet aggregation rates maintain such low levels at 3,6,12 months after treatment.There was significant difference in percentage of red blood cells(RBC),white blood cells(WBC) and neutrophil between pre-and post-treatment.Among these patients,1 presented with serious thrombopenia(TP)(0 89%),5 with minor bleeding(4 46%),1 with skin rash(0 89%),12 with a gastrointestinal discomfort(10 4%).Conclusion In general,long-term anti-platelet therapy of combined aspirin and clopidogrel is safe after implanting drug-eluting stents in CHD patients,but there still come about such complications as thrombocypenia,rash and bleeding.Follow-up and testing are needed in the course of medication." @default.
- W2347808618 created "2016-06-24" @default.
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- W2347808618 date "2008-01-01" @default.
- W2347808618 modified "2023-09-28" @default.
- W2347808618 title "Safety Evaluation of Long-term Anti-platelet Therapy of Combined Aspirin and Clopidogrel after Percutaneous Coronary Intervention" @default.
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