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- W2347811667 abstract "Objective To investigate the dominant genotypes of H.pylori(Hp) and its relationship to the resis-tance of antibiotics in Ningbo district.Methods Specimens of gastric mucosa were collected by biopsy from 40 patients,26 with chronic gastritis(CG) and 14 with peptic ulcer(PU) .PCR was conducted to detect the cagA,vac-Am1,vacAm2,vacAs1a and babA2 genotypes of Hp isolates.Antibiotic susceptibility test was performed by disk diffusion technique.Results The positive rates of cagA,vacAm1,vacAm2,vacAs1a and babA2 genotypes in 40 Hp strains were 100%,52.5%,85.5%,92.5%and 57.5%,respectively.There were no significant differences in the detective rates of HP genotypes between chronic gastritis and peptic ulcer(0.05) .Of 40 Hp strains,0 was re-sistant to amoxicillin,15%to azithromycin,7.5%to clarithromucin,22.5%to lavo-ofloxacin and 35%was resis-tant to metronidazole.Resistance rate of metronidazole was higher than that of azithromycin and significantly hig-her than that of amoxicillin and clarithromucin(0.01) ;the distributions of cagA,vacAm1,vacAm2,vacAs1a and babA2 genotypes were not significantly different between resistant strains and susceptibile strains of Hp to metronidazole(0.05) .Conclusion CagA,vacAm2,vacAs1a,babA2 and vacAs1a/m2 are the dominant geno-types of Hp in the CG and PU patients in Ningbo.The determination of subtypes of Hp gene is still not helpful to choose antibiotics in Hp eradication treatments." @default.
- W2347811667 created "2016-06-24" @default.
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- W2347811667 date "2010-01-01" @default.
- W2347811667 modified "2023-09-24" @default.
- W2347811667 title "Dominant genotypes of Hp and its relationship to antibiotics resistance in Ningbo district" @default.
- W2347811667 hasPublicationYear "2010" @default.
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