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- W2347863696 abstract "Objective The aim of this study is to determine the prevalence and distribution of HPV infection with cervical neoplasia in Chaozhou area and evaluate the association between the viral load of eight high risk human papillomavirus and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods 220 cases of abnormal liquid-based cytology women from Chaozhou central hospital were examinated with colposcopy and histopathological. Cervical specimens were tested for 21 HPV types using a MY09/MY11 L1 consensus primer PCR method with specific dot blot hybridization and viral load of eight high risk genotypes were tested by real-time PCR. Results Overall HPV infection prevalence was 87.3%(192/220) and HPV16 was the most prevalent genotype with a detection rate of 50.9% in our study. The detection rates of HPV and HPV16 raised with increasing of severity of cervical disease (P0.05). HPV58, HPV33, HPV52, HPV31 and HPV18 were the five most popular genotypes just less than HPV16 with detection rates of 22.73%, 11.82%, 11.36%, 5.9% and 4.54%, respectively. The viral load of high risk HPV was positive correlate with the severity of CIN and cervical cancer(r=0.373, P0.001). Conclusion Although HPV52 and HPV58 were the advantage genotypes of HPV infection in Chaozhou region, HPV16 was the main genotype of HPV infection in women with cervical lesion in this area, and the most related to cervical cancer were HPV16 and HPV18. The viral load of eight high risk human papillomavirus was a potential auxiliary indicators of cervical cancer and precancerous." @default.
- W2347863696 created "2016-06-24" @default.
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- W2347863696 date "2013-01-01" @default.
- W2347863696 modified "2023-09-25" @default.
- W2347863696 title "The detection of HPV genotyping and viral load of eight high risk human papillomavirus in cervical lesions" @default.
- W2347863696 hasPublicationYear "2013" @default.
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