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- W2347873009 abstract "Objective To identify the role of protein kinase C(PKC) activation in ischemic myocardium proctection and its effect after inhibition by polymyxin B sulfate.Methods We randomly divided 30 rabbits into ischemic(IS) group,ischemic preconditioning(IPC) group and polymyxin B sulfate(PMB) group.According to the method reported in previous literature,we simultaneously recorded ECG,pressure curve and monophasic action potential(MAP) throughout the ischemia and reperfusion perocess.Results The rabbit heart rates were not changed significantly during the ischemic or reperfusion period.The products of heart rate multiplying systolic pressure were significantly higher in IPC group compared with the other two groups(P0.05).The activation of PKC protected the systolic function of left ventricle but did not have the same effects on the diastolic function.There was no apparent shortening of MAP amplitude(MAPA),dv/dt max during the 5-20 min of ischemic period in IPC group compared with the other 2 groups.PMB might abolish the protective effect of IPC,reduced the conduction velocity of myocardial cells and relatively increased the repolarization dispersion.PKC deactivated by PMB could not increase the rates of electrical alternans,ventricular premature beats and ventricular fibrillation.Conclusion The activation of PKC might reduce the myocardial necrosis,improve the systolic function of left ventricle,but could not reduce the electrical alternans,ventricular premature beats and ventricular fibrillation.The anti-ischemic and anti-arrhythmic effects of PKC might not generate through the same pathways.PKC activation may not take part in anti-arrhythmia." @default.
- W2347873009 created "2016-06-24" @default.
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- W2347873009 date "2008-01-01" @default.
- W2347873009 modified "2023-09-28" @default.
- W2347873009 title "Inhibition of activated protein kinase C mediated ischemic myocardium protection by polymyxin B sulfate" @default.
- W2347873009 hasPublicationYear "2008" @default.
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