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- W2347883359 abstract "Objective To develop a simple,fast,sensitive,accurate method to monitor verapamil in human plasma samples.Methods To employ a SPE approach for plasma samples treatment;Gallo verapamil as internal standard,acetic acid-sodium acetate:methanol:triethylamine(45:55:1)as mobile phase,to detect by HPLC chromatography with fluorescence,fluorescence detection wavelength 275 nm.Results The peaks of verapamil and internal standard in the chromatograms can be well separated,no obvious peak of the impurity can be observed.The method have been validated and the linear range was 5 ～ 500 ng.mL-1,limit of detection was 1.4 ng.mL-1,limit of quantification was 5.0 ng.mL-1,the average recoveries were 90.7%,88.2% and 90.2%,and the value of RSD of the precision was less than 15%,the RSD value in the stability test are less than 20%.Conclusion The method is simple,fast,sensitive and accurate and can applicable to blood concentration monitoring of verapamil in clinical." @default.
- W2347883359 created "2016-06-24" @default.
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- W2347883359 date "2012-01-01" @default.
- W2347883359 modified "2023-09-25" @default.
- W2347883359 title "Determination of verapamil in human plasma by SPE-HPLC-FLU method" @default.
- W2347883359 hasPublicationYear "2012" @default.
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