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- W2347885420 abstract "The Caco-2 cell model, an intestinal endothelial model for transport study, was established to study the absorption mechanism of the antihypertensive peptides, Val-Pro-Pro(VPP) and Ile-Pro-Pro(IPP). The Caco-2 cell model was evaluated by morphological features, transepithelial electrical resistance and the transmittance of fluorescein sodium. We comparatively investigated the effects of transport time, peptide concentration, enhancers and inhibitors on the transport pathways and efflux mechanisms of VPP and IPP. The results showed the established Caco-2 cell model could be used to study the intestinal absorption of VPP and IPP. Paracellular diffusion was suggested to be the main mechanism for the absorption of the two antihypertensive peptides. The transports of both peptides were influenced by the efflux pump. The efflux affected VPP more than IPP. Thus, IPP showed higher bioavailability." @default.
- W2347885420 created "2016-06-24" @default.
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- W2347885420 date "2014-01-01" @default.
- W2347885420 modified "2023-09-23" @default.
- W2347885420 title "Establishment of Caco-2 Cell Model and Intestinal Absorption Mechanism of the Antihypertensive Peptides Val-Pro-Pro and Ile-Pro-Pro" @default.
- W2347885420 hasPublicationYear "2014" @default.
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