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- W2347886384 abstract "Objective To evaluate the healing behavior of rabbits articular cartilage defects repaired with tissue engineered cartilage constructed by acellular articular cartilage matrices(AACMs)seeded with adipose derived stem cells(ADSCs).Methods ADSCs with rabbit-induced were seeded in AACMs with rabbit-developed and cultured in chondrogenic differentiation medium for two weeks in order to construct tissue engineered cartilage.24 New Zealand white rabbits were divided into A,B and C groups randomly.Then engineered cartilage was transplanted into cartilage defect position of rabbits in the group A.AACMs was for the group B and nothing for the group C.The rabbits were killed in the 12th week.Restored tissue was evaluated using naked eyes,histology,immunohistochemistry and transmission electron microscope(TEM).Results In the group A,articular cartilage defects of the rabbits were filled with chondrocyte-like tissue which cells were positive of Alcian blue staining and type Ⅱ-collagen either in expression.The chondrocytes can be seen in the recesses and there were plenty of the matrix particles and collagen surrounding the cells with TEM scanning.In the group B,the defect was filled with fibrous tissue.No tissue was found in the group A.Conclusions Tissue engineered cartilage using AACMs seeded with ADSCs cultured in chondrogenic differentiation medium can be well repair of articular cartilage defects in rabbits.It has the potential to substitute for the normal cartilage." @default.
- W2347886384 created "2016-06-24" @default.
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- W2347886384 date "2009-01-01" @default.
- W2347886384 modified "2023-09-24" @default.
- W2347886384 title "The initial study on repair of rabbit articular cartilage defects using tissue engineered cartilage constructed with adipose derived stem cells" @default.
- W2347886384 hasPublicationYear "2009" @default.
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