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- W2347937839 abstract "AIM:To examine the effects of toluidine blue(TB)-mediated photodynamic therapy(PDT) for oral wound infections in mice.METHODS:1mg/ml of TB and a red light with dose of 12 J/cm2 and 48 J/cm2 were combined in the experiment to evaluate the bactericidal effect and change of lesion size.RESULTS:About 93% bacteria in the wound was killed when a light dose of 48 J/cm2 was used,which achieved the best bactericidal effect.but an ideal killing effect was not achieved in the group with 12 J/cm2(average 15% bacteria survived).After PDT,the lesion was not stopped from developing,but the peak size of lesion was larger obviously in the control group than that in the test groups,especially for the 48 J group.In the following days,the 12 J and 48 J group also showed significantly less size of lesion.CONCLUSION:Our study has demonstrated that the TB-PDT can cure oral wound infections in mice.These promising results suggest that the potentiality of this regimen may be a possible alternative to topical antimicrobials in future clinical applications." @default.
- W2347937839 created "2016-06-24" @default.
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- W2347937839 date "2009-01-01" @default.
- W2347937839 modified "2023-09-22" @default.
- W2347937839 title "Toluidine blue-mediated photodynamic therapy of oral wound infected with Staphylococcus aureus in rats" @default.
- W2347937839 hasPublicationYear "2009" @default.
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