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- W2347944934 abstract "Objective:To study the role of glycemia in advanced glycated end products(AGE) mediated endothelin 1 (ET 1) induction.Methods:We grouped patients with type II diabetes according to the levels of HbA 1c:(HbA 1c6%?HbA 1c 6.0 %～ 8.0 % and HbA 1c 8.0 %).ET 1 was induced by incubation of BAECs with erythrocytes isolated from patients with different HbA 1c levels. ET 1 was determined by a radioimmunoassay. Western blot analysis was used to evaluate content of CML modified proteins in erythrocytes. RT PCR for ET 1 showed the expression of ET 1 mRNA. NF kB binding activity was monitored in EMSA.Results:Erythrocytes which derived from patients with poor glycemic control had more CML modified proteins and a stronger ET 1 inducing activity in cultured BAECs than erythrocytes derived from patients with good glycemic control. Their NF κB inducing activity was significant stronger than control. This study also indicates that CML modified proteins not only increase ET 1 concentration but also increase the expression of ET 1 mRNA in BAECs.Conclusion:AGE mediated ET 1 induction by NF kB activation is dependent on hyperglycemia. It may relate to the mechanism of vascular complication of diabetes. Control of hyperglycemia is the key issue to reduce ET 1 induction and prevention vascular complications of diabetes." @default.
- W2347944934 created "2016-06-24" @default.
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- W2347944934 date "2003-01-01" @default.
- W2347944934 modified "2023-09-22" @default.
- W2347944934 title "Advanced glycated end products mediated endothelin-1 induction" @default.
- W2347944934 hasPublicationYear "2003" @default.
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