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- W2347949530 abstract "AIM: To investigate the effect of calcitonin gene-related peptide(CGRP) on the proliferative potential of HaCaT keratinocytes and whether CGRPR and ERK1/2 pathway is involved in this progress.METHODS: -TdR test was used to estimate the CGRP-induced proliferative potential of HaCaT keratinocytes and the influence of CGRP8-37(CGRP receptor 1 antagonist) and PD98059(ERK1/2 inhibitor) on this effect.Western blotting was used to test the activation of ERK1/2 pathway.RESULTS: Exposure of HaCaT keratinocytes to CGRP induced proliferation through the CGRP receptor and ERK1/2 pathway.CGRP 8-37 and PD98059 inhibited CGRP-induced proliferation of HaCaT keratinocytes.Phosphorylation of ERK1/2 was activated by CGRP in a time-dependent manner,which was inhibited by CGRP 8-37 and PD98059.CONCLUSION: This study indicates that CGRP triggers the proliferation of HaCaT keratinocytes by CGRP receptor and ERK1/2 signaling pathway." @default.
- W2347949530 created "2016-06-24" @default.
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- W2347949530 date "2007-01-01" @default.
- W2347949530 modified "2023-09-28" @default.
- W2347949530 title "Calcitonin gene-related peptide triggers proliferation in HaCaT keratinocytes by ERK1/2 signaling pathway" @default.
- W2347949530 hasPublicationYear "2007" @default.
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