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- W2347951004 abstract "Objective: To study first-phase insulin secretion in subjects with impaired glucose tolerance(IGT) and newly diagnosed type 2 diabetes mellitus(DM).Methods: A total of 90 subjects[twenty-eight normal control(NC) subjects,31 patients with impaired glucose tolerance(IGT),and 31 patients with newly diagnosed type 2 diabetes mellitus(DM)]underwent 75g oral glucose tolerance test and insulin-modified reduced sample number(n=12) of Bergman′s minimal model method with frequently sampled intravenous glucose tolerance test(FSIGTT).Insulin secretion was determined by Homa β-cell function index(HBCI),ΔI30/ΔG30 and acute insulin response(AIR)to glucose,respectively.Meanwhile the anthropometrical parameters including body mass index(BMI) and waist hip ratio(WHR) were evaluated and the serum lipid profile,plasma glucose,insulin and HbA1c levels were also measured. Results:(1) The AIR in DM group[27.4(-2.5-76.5) mU/L]was significantly lower than that in NC(270.5±128.3 mU/L) and IGT[213.3±154.4 mU/L]groups(P0.01),and there was no significant difference between IGT and NC groups.(2) The ΔI30/ΔG30(1.1±0.6) and HBCI(3.8±1.0) in DM group were significantly lower than that in NC(2.7±0.9,4.2±1.0,respectively.) and IGT(2.5±1.0,4.9±1.7,respectively.) groups(P0.01),and there was no significant difference between IGT and NC groups.(3) As to AIR level,it was positively correlated with ΔI30/ΔG30,HBCI,insulin and BMI.(P0.05～0.01),and negatively correlated with glucose,age,HbA1c and insulin sensitivity index(SI)(P0.05～P0.01).After adjustment for BMI and age,ΔI30/ΔG30,HBCI and insulin remained positively correlated with AIR.Glucose and HbA1c remained negatively correlated with AIR.(4) In general multivariate regression,BMI and ΔI30/ΔG30 were significantly independent determinants for AIR(r2=0.656,P0.01). Conclusion: The AIR decreased in newly diagnosed type 2 DM group,and was positively correlated with HBCI,especially with ΔI30/ΔG30.It suggests that ΔI30/ΔG30 can be served as a clinical evaluation index of insulin secretion." @default.
- W2347951004 created "2016-06-24" @default.
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- W2347951004 date "2009-01-01" @default.
- W2347951004 modified "2023-09-24" @default.
- W2347951004 title "Study on insulin secretion in the subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes mellitus" @default.
- W2347951004 hasPublicationYear "2009" @default.
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