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- W2347972827 abstract "OBJECTIVE: To investigate the effects of mitomycin (MMC) combined with celecoxib on the proliferation of superficial bladder cancer cell line T24 and the possible mechanism. METHODS: The superficial bladder cancer T24 cell line were cultured in vitro, and divided into MMC groups [0 (control group), 2, 5, 10, 25 and 50 μmol/L] and MMC combined with celecoxib (50 μmol/L) group with each concentration of 5 bores. MTT method was used to detect the proliferation inhibition rate after 24 h. Immunohistochemistry assay, RT-PCR and ELISA method were adopted to detect the expression of Bcl-2 protein after 48 h of treatment and VEGF mRNA after 24 h of treatment and the protein concentration of VEGF within 96 h of treatment in control group、 MMC (50 μmol/L) group and mixture [celecoxib+MMC (50 μmol/L)] group. RESULTS: MMC could inhibit the proliferation of T24 cell (P0.05), in dose dependent manner; celecoxib could significantly enhance the inhibitory effect of MMC (P0.05). Compared with control group, the expression of Bcl-2 protein and VEGF mRNA were decreased significantly in MMC group and celecoxib+MMC group (P0.05); there was statistical significance between the latter 2 groups (P0.05). The concentration of VEGF protein in celecoxib+MMC group was decreased significantly statistically with time (P0.01). CONCLUSIONS: Celecoxib can collaboratively enhance inhibitory effect of MMC on the proliferation of T24 cell. The mechanism may be related to reducing the expression of Bcl-2 and VEGF mRNA and inhibiting the secretion of VEGF protein." @default.
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- W2347972827 date "2013-01-01" @default.
- W2347972827 modified "2023-09-25" @default.
- W2347972827 title "Effects of Mitomycin Combined with Celecoxib on the Proliferation of Bladder Cancer Cell Line T24" @default.
- W2347972827 hasPublicationYear "2013" @default.
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