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- W2347973485 abstract "[Objective] To observe the clinical value of insulin-like growth factor(IGF)-1 and IGF binding protein(IGFBP)-3 in diagnosis and therapeutic effect judging of growth hormone deficiency(GHD)in children.[Methods] 68 children with GHD were treated with China-made recombinant human growth hormone(r-hGH) for 12 months,the dosage was 0.1 IU/(kg·d).The height,body weight,bone age,serum IGF-1 and IGFBP-3 levels were measured before and after 3,6,12 months of the treatment.The results were compared with those of 60 normal children.[Results] The levels of serum IGF-1 and IGFBP-3 in GHD children were significantly lower than those of normal children(P0.01).The growth velocities after 3,6 and 12 months therapy were significantly increased compared with the pretreatment.The levels of serum IGF-1 and IGFBP-3 were also significantly increased.The level of IGF-1 in pretreatment was correlated negatively to the growth velocity after 6 and 12 months of treatment(r =-0.72 and 0.70,P0.01).The changes of IGFBP-3 after 3 months treatment were correlated positively with the growth velocity after 6 and 12 months of treatment(r=0.82 and(0.80),P0.01).[Conclusion] Serum IGF-1,IGFBP-3 levels may serve as useful parameters in the diagnosis of GHD and in the predicting of r-hGH therapy effect." @default.
- W2347973485 created "2016-06-24" @default.
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- W2347973485 date "2006-01-01" @default.
- W2347973485 modified "2023-09-23" @default.
- W2347973485 title "The clinical application of IGF-1 and IGFBP-3 in the diagnosis and therapeutic effect judging of growth hormone deficiency in children" @default.
- W2347973485 hasPublicationYear "2006" @default.
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