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- W2347998728 abstract "Objective: To investigate the effect of pinealectomy and melatonin on the T cells development in thymus. Methods: SD rats were divided into 5 groups: normal control, sham-operation control, pinealectomy (Px), pinealectomy+melatonin 7.5 mg/kg, and pinealectomy+melatonin 15 mg/kg group. The animals were sacrificed on 4 or 8 weeks after operation. CD4~+ and CD8~+ T cells in thymus were dyed with immunocytochemical ABC methods and measured by computer image analysis. The percentage of CD4~+ and CD8~+ T cells subset in thymus and blood were tested by flow cytometry. Results: Pinealectomy reduced the rat thymus weight, and treatment with melatonin restored it. The variation of CD4~+ T cells in thymus and blood was not obvious after Px. The percentage of CD8~+ T cells in thymus increased but decreased in blood. The percentage of CD8~+ T cells in thymus and blood both decreased. The CD4~+ and CD8~+ T cells restored to normal and CD4~- and CD8~- T cells were raised. Conclusion:Pinealectomy can notably influence the T cell subsets development in thymus, decease CD8~+ T cells in blood. Melatonin administration can recover the above mentioned changes." @default.
- W2347998728 created "2016-06-24" @default.
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- W2347998728 date "2005-01-01" @default.
- W2347998728 modified "2023-09-25" @default.
- W2347998728 title "Effects of pineal gland and melatonin on CD4~+/CD8~+ T cell subsets development in rat thymus" @default.
- W2347998728 hasPublicationYear "2005" @default.
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