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• W2348002754 abstract "Objective To investigate the protective effects of Edaravone on lung in smoke inhalation injury in rats. Methods Thirty-two male Sprague-Dawle (SD) rats were randomly divided into four groups ( n =8) : normal control group (group A) ,injured group (group B) ,Edaravone prevented group (group C) and Edaravone treated group (group D) . Ten minutes before smoke inhaled injured,the rats in group C were all injected intraperitoneally with Edaravone (9mg/kg) ,while 30 minutes after smoke inhaled injured,the rats in group D were all injected intraperitoneally with Edaravone ( 9 mg / kg) ,and at the same time the group B were injected the same volume normal saline. The rats were treated by no means in the control group. Every group collected the blood samples 5 mL from femoral artery and the lung tissue after smoke inhaled injured at the time of 6 hours. The samples were centrifugalized and tested the levels of tumor necrosis factor-α ( TNF-α) ,interleukin-6 ( IL-6) ,interleukin-10 ( IL-10) in serum as well as the levels of malondialdehyde ( MDA) ,myeloperoxidase ( MPO) ,superoxide dismutase ( SOD) in lung tissues. The histopathological examination was performed with the tissue specimens taken from the apex of right lung. Results Compared with group B,remarked decreases were found in the TNF-α ( 311. 8 ± 7. 90) pg /mL vs ( 399. 3 ± 8. 03) pg/mL,IL-6 ( 229. 3 ± 7. 01) pg/mL vs ( 367. 2 ± 22. 67) pg/mL,MDA ( 4. 27 ± 0. 06) nmol / mg vs ( 6. 30 ± 0. 09) nmol / mg,MPO ( 46. 22 ± 0. 44) U / g vs ( 72. 68 ± 1. 14) U / glevels in group D ( P ﹤0. 01) ,while the levels of SOD ( 148. 53 ± 2. 18) U / mg vs ( 100. 05 ± 1. 03) U / mg and IL-10 ( 264. 7 ± 5. 37) pg / mL vs ( 232. 3 ± 7. 62) pg / mLwere increased ( P 0. 05) ,and the expressions of the above factors were more evident in group C ( P 0. 01) . Histopathological examination showed that inflammatory granulocytes and edema were improved in group C and group D compared with group B. Conclusions Edaravone has protective effects on smoke inhalation injured by anti-oxygen free radical and inhibiting inflammatory mediators production. The effect of Edaravone on smoke inhalation injury is better in prevention." @default.
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• W2348002754 date "2013-01-01" @default.
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• W2348002754 title "Preventive effect of Edaravone on lung in smoke inhalation injury in rats" @default.
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