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- W2348006144 abstract "AIM To determine the concentration of mitiglinide in human plasma by LC-MS/MS and to study its pharmacokinetics.METHODS Acidified plasma samples were prepared by a simple liquid-liquid extraction with ethyl acetate.The chromatographic separation was performed on an Agilent Zorbax Eclipse Plus C_(18) column with a mobile phase of methanol -10 mmol·L~(-1) ammonium acetate solution.Analytes were detected with an Agilent 6410 Triple qudrupole mass spectrometer equipped with an electrospray ionization source in positive multiple reaction monitoringmode:m/z 316.2 (precursor ion) to 298.2 (product ion) for mitiglinide and m/z 318.2 (precursor ion) to 120.2(product ion) for the internal standard.RESULTS The standard curve was linear (r=0.995) over the concentration range of 0.502 0-4 016μg·L~(-1).Accuracy and precision were all within±15%.The lower limit of quantification for mitiglinide was 0.502 0μg·L~(-1).The linear pharma- cokinetics was detected in plasma concentrations of the single oral dose of 5 mg,10 mg and 20 mg group in these healthy volunteers.CONCLUSION A rapid,sensitive and simple LC-MS/MS method for determination of mitiglinide was development,and the assay was successful applied to a clinical pharmacokinetic study." @default.
- W2348006144 created "2016-06-24" @default.
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- W2348006144 date "2008-01-01" @default.
- W2348006144 modified "2023-09-22" @default.
- W2348006144 title "Determination of mitiglinide in human plasma by LC-MS/MS and study of pharmacokinetics" @default.
- W2348006144 hasPublicationYear "2008" @default.
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