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- W2348013512 abstract "Objective To investigate the protective effect of a-lipoic acid on patients with stage IV diabetic nephropathy(DN).Methods 66 patients with stage IV DN were randomly divided into conventional treatment group(conventional group) and a-lipoic acid group(observation group),2 groups' after treatment blood pressure,blood sugar,blood lipids,serum superoxide dismutase(SOD),malondialdehyde(MDA),urinary albumin excretion rate(UAER),urinary(3,-microglobulin(β_2-MG),creatinine(SCr),blood urea nitrogen(BUN) changes was observed.Another 20 cases of healthy people selected as healthy control group.Results Conventional group and observation group before and after treatment,differences of blood pressure,blood glucose,blood lipids were not statistically significant(P 0.05),while the FPG,2hPG,HbA,,.higher than the healthy control group(P 0.05);before treatment,conventional group and the observation groups MDA,UAER,(3,- MG were higher than the healthy control group,SOD lower than the control group(P 0.05).After treatment,the two groups' UAER,β_2-MG decreased,observation group decreased more significantly than the conventional group(P 0.05);after treatment,in the observation group,MDA decreased and SOD increased,and letter than the conventional group(P 0.05).Conclusion a-lipoic acid can effectively control proteinuria of stage Ⅳ DN,slow DN progress,play a protective role for the kidneys." @default.
- W2348013512 created "2016-06-24" @default.
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- W2348013512 date "2014-01-01" @default.
- W2348013512 modified "2023-09-22" @default.
- W2348013512 title "Protective effect of α-lipoic acid on patients with stage IV diabetic nephropathy" @default.
- W2348013512 hasPublicationYear "2014" @default.
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