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- W2348014149 abstract "AIM:To investigate the effects of p38 mitogen-activated protein kinase(MAPK) signaling pathway on the odontoblastic differentiation of human dental pulp cells(hDPCs).METHODS:Tissue block enzymolytic method was used to isolate and culture hDPCs.hDPCs of Passage 3 was cultured with mineralization inducing medium containing 20 μmol/L SB203580,a p38 MAPK inhibitor.Cells cultured without SB203580 served as the controls.7 days after induction,quantitative real-time RT-PCR was conducted to detect the mRNA expression of dentin sialophosphoprotein(DSPP) and osteonectin(OCN).Alkaline phosphatase(ALP) staining and alizarin red S staining were used to examine ALP activity and mineralized nodule formation at 14 d and 28 d after induction,respectively.RESULTS:SB203580 downregulated DSPP,ALP and OCN expression,suppressed ALP activity and mineralized nodule formation.CONCLUSION:The p38 MAPK inhibitor SB203580 inhibited the differentiation and mineralization of hDPCs,indicating that p38 MAPK signaling pathway may be involved in hDPCs odontoblastic differentiation." @default.
- W2348014149 created "2016-06-24" @default.
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- W2348014149 date "2013-01-01" @default.
- W2348014149 modified "2023-09-23" @default.
- W2348014149 title "Effects of p38 MAPK signaling pathway on the odontoblastic differentiation of human dental pulp cells" @default.
- W2348014149 hasPublicationYear "2013" @default.
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