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- W2348014846 abstract "Objective:To detect the expressions of multidrug resistance gene ATP-binding cassette superfamily G member 2( ABCG2) in JEG-3 cells( human choriocarcinoma cell line) and JEG-3 /VP16 cells( drug resistant human choriocarcinoma cell line) and to investigate the relationship between ABCG2 and drug-resistance mechanism of choriocarcinoma. Methods:The mRNA and protein expressions of ABCG2 were analyzed by RT-PCR and western blot,flow cytometry was used to figure out the percentages of ABCG2-positive cells in the two choriocarcinoma cell lines. Results:ABCG2 were expressed in both JEG-3 cells and JEG-3 /VP16 cells,but the expression of ABCG2 in JEG-3 /VP16 cells was much higher than that in JEG-3 cells( P0. 01). And according to the results of flow cytometry,the positive cell rates of ABCG2 in JEG-3 /VP16 cells is much higher than that in JEG-3 cells( P0. 01). Conclusions:ABCG2 is highly expressed in the JEG-3 /VP16 cells,which indicates ABCG2 may be involved in the drug resistance mechanism of choriocarcinoma." @default.
- W2348014846 created "2016-06-24" @default.
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- W2348014846 date "2013-01-01" @default.
- W2348014846 modified "2023-09-26" @default.
- W2348014846 title "The Expression of ABCG2 in the Drug Resistant Human Choriocarcinoma Cell Line" @default.
- W2348014846 hasPublicationYear "2013" @default.
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