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- W2348016864 abstract "OBJECTIVE:To investigate the effects of the aberrant hypermethylation of BRCA1 promoter on the expression of BRCA1 protein,and relate to the happening and development of sporadic breast cancer.METHODS: For selected 51 sporadic breast infiltrating ductal carcinoma tissues and 10 benign breast tissues,the methylation status of BRCA1 promoter was analyzed by methylation specific PCR(MSP),and the expression level of BRCA1 protein was detected by immunohistochemistry(IHC).RESULTS: There were unmethylation of BRCA1 promoter in 10 tissues of benign breast tissues,and the positive expression of BRCA1 protein in the nuclei.In 51 sporadic breast infiltrating ductal carcinoma tissues,7(13.73%) carcinoma tissues had hypermethylation of BRCA1 promoter,44 cases had unmethylation of BRCA1 promoter,and the proportion was 86.27%(44/51).For all of the 7 hypermethylated cases,the expression of BRCA1 protein was not detected in the nuclei(0/7),for 1 of 7 cases the expression of BRCA1 protein was detected in the cytoplasma.For the 44 unmethylated tissues,the nuclei positive expression of BRCA1 protein was found in 30 tissues(68.18%),the nuclei negative expression of BRCA1 protein in 14 tissues(31.82%).The methylation of BRCA1 promoter had significant relationship with the expression grade of BRCA1 protein,χ2=11.959 1,P=0.000 5;the expression of BRCA1 had a significant difference between the benign breast tissues and the sporadic breast infiltrating ductal carcinoma tissues,χ2=4.587 9,P=0.032.CONCLUSION: Promoter hypermethylation of BRCA1 inhibits the expression of BRCA1 protein and influences its participation in the happening and development of sporadic breast cancer." @default.
- W2348016864 created "2016-06-24" @default.
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- W2348016864 date "2007-01-01" @default.
- W2348016864 modified "2023-09-28" @default.
- W2348016864 title "Relationship between the methylation status of BRCA1 promoter and the expression of BRCA1 protein in sporadic breast cancer" @default.
- W2348016864 hasPublicationYear "2007" @default.
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