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- W2348028947 abstract "Objective:To investigate the inhibitory effect of gastrodine on the oxidative modification of low density lipoprotein(Ox-LDL)in mouse peritoneal msacrophages(MP).Methods:MPs were used to mediate the oxidation of human LDL.The effect of gastrodine on the biochemical changes in MP cells was observed by determining malonaldehyde and activity of glutathione peroxidase(GPX),and by oil red O staining and scavenger receptor immunohistochemical staining.Results:As compared with MP cells treated with LDL alone,the level of lipid peroxide(LPO)was dramatically decreased,and activity of GPX was increased in MP cells treated with LDL plus gastrodine.Therefore,the pathological role of Ox-LDL in MPs was reduced.The scavenger receptor activity declined in the cells treated with gastrodine,leading to the reduction in lipid accumulation.Conclusion:Gastrodine has an importantly inhibitory effect on human LDL oxidation and the cellular damage induced by Ox-LDL." @default.
- W2348028947 created "2016-06-24" @default.
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- W2348028947 date "2009-01-01" @default.
- W2348028947 modified "2023-09-24" @default.
- W2348028947 title "Inhibitory effect of gastrodine on the oxidative modification of low density lipoprotein in mouse peritoneal macrophages" @default.
- W2348028947 hasPublicationYear "2009" @default.
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