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- W2348083496 abstract "AIM To study the effects of L tetrahydropalmatine (L THP) on extracellular matrix (ECM) proliferation in hypertrophic myocardium of rats caused by pressure overload. METHODS The model (PO, n =10) was established with banding of abdominal aorta (PO). Collagen volume fraction (CVF) and perivascular collagen area (PVCA) were measured with Van Gieson staining to observe the severity of ECM proliferation. Myocardium transverse diameter (TDM) was measured with HE staining to observe myocardium hypertrophy. The group of PO+ L THP (LT, n =10) was given L THP (approximately 1 mg·g -1 weight per day orally in Drinking) from 3 days before the surgery to 12 weeks after it. The group of sham operated (SO, n =10) was used as control. RESULTS TDM、 CVF and PVCA were markedly increased (TDM: P 0 05; CVF and PVCA: P 0 01)in PO group than those in LT group and in SO group. CONCLUSION Myocardial hypertrophy and myocardial ECM proliferation can be caused by PO, and L THP markedly reduces this kind of effect." @default.
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- W2348083496 date "2001-01-01" @default.
- W2348083496 modified "2023-09-25" @default.
- W2348083496 title "Effects of L-tetrahydropalmatine on extracellular matrix proliferation of rats in hypertrophic myocardium caused by pressure overload" @default.
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