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- W2348085770 abstract "Objective: To compare the effects of ganciclovir eye gel and acyclovir eye drops on simple herpes keratitis.Methods: A total of 128 patients were randomly divided into control group and observation group,the observation group was treated with topical application of 0.15% ganciclovir eye gel,while the control group was given 0.1% topical acyclovir eye drops.After 2 weeks of treatment,status such as eye irritation,bulbar conjunctiva ciliary hyperemia and improvement of cornea symptoms were recorded and compared between the two groups.Results: Of the 64 eyes of the treatment group 34 were healed,with and curative rate of 53.0%,30 showed improvements indicating a total efficiency of 100.0%.For the control group,12 of 64 eyes were cured(19.0%);28 were improved,and 24 showed no improvement,the total efficiency of the control group was 62.5%.No side effects was observed in the observation group,but ocular pain which was tolerable was observed in 4 cases of the control group,ciliary congestion of the bulbar conjunctiva after treatment occurred in other 4 cases.According to follow up of 12 months,2(6.0%) and 8 cases(67.0%) of recurrence were observed in the observation group and control group,respectively.Significant difference in curative rate,total efficiency rate,recurrence rate and incidence of side effects were observed(P0.05).Conclusions: Ganciclovir ophthalmic gel is more effective on simple herpes keratitis than acyclovir eye drops,it produce longer term efficiency but induce lower side effects,and lower recurrence rate,thus it's an optimum treatment for herpes simple keratitisand and is worthy of clinical application." @default.
- W2348085770 created "2016-06-24" @default.
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- W2348085770 date "2012-01-01" @default.
- W2348085770 modified "2023-09-28" @default.
- W2348085770 title "Effect comparison of two drugs on simple herpes keratitis" @default.
- W2348085770 hasPublicationYear "2012" @default.
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